Paget's Disease of Bone
Paget's Disease of Bone
It is a chronic disease in which bones grow abnormally, weaken, and their transformation is affected. Paget's disease of bone It is usually a progressive condition and causes bones to lose their normal structure, becoming brittle and leading to deformity.
In people with Paget's disease, bones remodel more quickly than normal. The new cells become larger and less organized than normal. This causes it to grow, weaken and become fragile. It is characterized by excessive bone resorption and formation.
What are the symptoms of Paget's disease of bone?
- Symptoms of the disease may vary depending on the progression of the disease and the type of bones it affects. However, in general, the following symptoms may occur:
- There may be pain in the bones, usually felt in the affected areas and increases with movement.
- Deformities may develop due to abnormal growth. These deformities can be seen especially in areas such as the legs, hips, spine and skull.
- Fractures may occur more frequently in people with Paget's disease. The risk of fracture may increase in areas such as hip, thigh, spine and wrist.
- It can cause stiffness and limited movement in joint areas near the affected areas. This condition may affect daily activities.
- Paget's disease of bone When it affects the skull, symptoms such as headache, dizziness and hearing loss may occur.
- Since the body rapidly replaces normal bone tissue, it may increase energy consumption and cause a feeling of fatigue.
- As it affects the bones of the spine, it can cause compression and slippage, which can lead to shortened height.
What are the Causes of Paget's Disease of Bone?
Experts think that the disease develops due to the interaction of genetic and environmental factors. Family history, genetic mutations or hereditary factors may increase the risk of the disease. Some viruses are thought to cause this disease. For example, rabies and measles viruses are among the possible viral agents.
Factors related to the immune system bone paget's disease It is thought that it may be effective in development. Immunological disorders can lead to abnormal changes in the bone turnover process. In addition, it is thought that environmental factors may also play a role in the development of the disease.
Is Bone Paget's Disease Hereditary?
This disease often has a hereditary predisposition, meaning family history may increase the risk of developing this disease. However, the exact mode of inheritance and genetic mechanisms of the disease are not fully understood. There is some evidence to suggest that hereditary factors contribute to Paget's disease. For example, more than one person in the same family may have Paget's disease. Additionally, some genetic mutations or genetic variations may increase the risk of developing the disease.
Hereditary predisposition may increase the likelihood of developing the disease, but other environmental factors may also need to be effective for the disease to occur. Mutations in the SQSTM1 gene bone paget's disease It is known to be associated with . This gene encodes sequestosome 1, a protein that plays an important role in the bone turnover process and affects the improper breakdown of cells.
Consequently, more research is needed on environmental and genetic factors that influence the risk of developing the disease. People with a family history should be monitored regularly for early signs or risk factors of the disease.
With treatment and appropriate management strategies for Paget's disease, symptoms can be controlled and complications can be prevented, allowing the person to live a healthy life. To maintain bone health, it is necessary to engage in regular physical activity, have a balanced diet, control calcium and vitamin D levels, and avoid harmful habits such as smoking.
Rarely, people may experience complications such as bone fractures, joint problems, or hearing loss. However, these complications can be prevented or controlled with appropriate treatment and management strategies. Since each individual's situation is different, it is important to get guidance from a specialist doctor about the treatment process. Paget's disease of bone It is recommended that you consult a specialist when you feel the symptoms.