Paget's Disease of Bone

Paget's Disease of Bone

It is a chronic disease in which bones grow abnormally, weaken, and their transformation is affected. Paget's disease of bone It is usually a progressive condition. It causes bones to lose their normal structure. It causes brittleness and deformity.

In people with the disease, bones remodel faster than normal. The new cells become larger and less organized than normal. This causes it to grow, weaken and become fragile. It is characterized by excessive bone resorption and formation.

What are the symptoms of Paget's disease of bone?

Paget's Disease of Bone

The symptoms of the disease vary depending on the progression of the disease and the type of bones it affects. There may be pain in the bones, usually felt in the affected areas and increases with movement.

Deformities may develop due to abnormal growth. These deformities can be seen especially in areas such as the legs, hips, spine and skull. Fractures may occur more frequently in people with this disease.

The risk of fracture may increase in areas such as hip, thigh, spine and wrist. It can cause stiffness and limited movement in joint areas near the affected areas. This condition may affect daily activities.

Paget's disease of bone When it affects the skull, symptoms such as headache, dizziness and hearing loss may occur. It can increase energy consumption as the body rapidly replaces normal bone tissue. The person may feel tired. As the bones of the spine are affected, they can become compressed and misaligned, which can lead to shortened height.

What are the Causes of Paget's Disease of Bone?

Experts think that the disease develops due to the interaction of genetic and environmental factors. Family history, genetic mutations or hereditary factors may increase the risk of the disease. Some viruses are thought to cause this disease. For example, rabies and measles viruses are among the possible viral agents.

Factors related to the immune system bone paget's disease It is thought that it may be effective in development. Immunological disorders can lead to abnormal changes in the bone turnover process. In addition, it is thought that environmental factors may also play a role in the development of the disease.

Is Bone Paget's Disease Hereditary?

This disease often has a hereditary predisposition, meaning family history may increase the risk of developing this disease. However, the exact mode of inheritance and genetic mechanisms of the disease are not fully understood. There is some evidence to suggest that hereditary factors contribute to the disease. For example, it can be seen in more than one person from the same family. Additionally, some genetic mutations or genetic variations increase the risk of developing the disease.

Hereditary predisposition may increase the likelihood of developing the disease. However, other environmental factors may also need to be effective for the disease to occur. Mutations in the SQSTM1 gene bone paget's disease It is known to be associated with . More research is needed on environmental and genetic factors that affect the risk of the disease. People with a family history should be monitored regularly for early signs or risk factors of the disease.

Healing Process

With treatment and appropriate management strategies, symptoms can be controlled. Complications can be prevented and a person can live a healthy life. It is important to engage in regular physical activity to maintain bone health. It is necessary to have a balanced diet and control calcium and vitamin D levels. It is also necessary to stay away from harmful habits such as smoking.

Complications such as bone fractures, joint problems, and hearing loss rarely occur in people. However, these complications can be prevented with appropriate treatment and management strategies. It can be controlled. Every individual's situation is different. For this reason, it is important to get guidance from a specialist doctor about the treatment process. Paget's disease of bone symptoms It is recommended that you consult a specialist when you feel